Beilstein J. Org. Chem.2013,9, 1333–1339, doi:10.3762/bjoc.9.150
against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC50 = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).
Keywords: Abiesbalsamea; cycloartane
]. Since then, more than 277 secondary metabolites have been isolated, and mainly identified as terpenoids, flavonoids and lignans [3]. Balsam fir Abiesbalsamea (L.) Mill., a popular Christmas tree in Canada, has been used traditionally by North American aboriginal people as an antiseptic, tuberculosis